Testing a vaccine made from a person's own cells, along with standard treatment for new glioblastoma
Original title: A Phase I First-in-human Trial of Bvax (B-cell Vaccination) in Addition to Standard of Care Chemoradiotherapy for Newly Diagnosed Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a first safety test of a new vaccine in people.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests adding a vaccine, made for each person, to the usual first treatment for glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary.
Who this trial is for. This trial is for people who were just diagnosed with glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary, a kind of brain tumor. It tests a vaccine called Bvax, made for each person, given along with standard chemotherapy and radiation.
Where it stands. This is the first time Bvax is being tested in people. The team wants to learn if it is safe, if it can be made and given as planned, and whether there are any early signs it helps. The trial has not reported results. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: Someone who was just diagnosed with glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary could ask their care team about this study. The care team can say whether it might fit their situation.
What it doesn't mean: This does not mean the vaccine works. A trial is a test, not a proven treatment. Being in one is not a guarantee that it will help. It is not a promise of a cure.
Source: ClinicalTrials.gov, September 25, 2026 · Read the original
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