Testing a targeted radiation drug with lomustine for glioblastoma that has come back
Original title: Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a large, late stage trial in people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial is testing whether adding a targeted radiation drug to lomustine helps adults whose glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary has come back.
Who this trial is for. This trial is for adults whose glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary has come back for the first time. It tests a drug called TLX101-Tx, which sends radiation straight to glioblastoma cells. Some people get it along with lomustine. Others get lomustine alone.
Where it stands. This trial has not reported results. Part 1 checks safety and the right radiation dose. Part 2 compares the two treatments to each other. It is looking at how well the drug works and how safe it is. The answer is not in yet.
What this means, and what it doesn't
What it could mean: This drug is still being tested. Nobody knows yet if it helps. If your glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary has come back, you could ask your care team about this trial. They can help you think through whether it fits your situation.
What it doesn't mean: This does not mean the drug works. A trial is a test, not a proven treatment. Being in one is not a guarantee that it will help you. It is not a promise of a cure.
Source: ClinicalTrials.gov, August 11, 2026 · Read the original
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