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Testing a smaller treatment edge in radiosurgery for tumors that spread to the brain

Original title: Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases

How far along is this research?

This is a trial that is enrolling or has been updated. It is not a finding yet.

This study lists no phase, so we treat it as an early test in people.

Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.

The trial team last updated this record on . Always check the trial page for the latest.

The short version

This trial is comparing two sizes of the treated area around a brain tumor during focused radiation.

Who this trial is for. This trial is for people with brain metastases, meaning tumors that spread to the brain, that are 4 cm or less across at their widest point. It compares treating with a 0mm margin to treating with a 2mm margin, which is a small rim of extra area around the tumor.

Where it stands. There are no results yet. The trial is comparing the 0mm margin with the 2mm margin. The answer about how the two compare is not in yet. The source reports no findings.

What this means, and what it doesn't

What it could mean: Doctors do not yet know if the smaller margin works as well as the larger one. Someone who fits this picture could ask their care team about it. Your team can say if a trial like this makes sense for you.

What it doesn't mean: This does not mean a new treatment has been proven. A trial is a test, not proven care. Joining a trial is not a guarantee that you will be helped. This is not a promise of a cure.

Source: ClinicalTrials.gov, July 30, 2026 · Read the original

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