Testing a slower way to give whole brain radiation to protect thinking and memory
Original title: Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage trial, so the approach has been tried in people but is still being tested.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial is testing whether giving whole brain radiation in a slower, pulsed way is better for a person's thinking and memory.
Who this trial is for. This trial is for people who are having radiation to the whole brain. It tests a way of giving that radiation called pulsed reduced dose rate, or PRDR. The plan is a dose of 30 Gy given in 10 fractions, with one treatment each day, starting within 14 days of signing up.
Where it stands. There are no results yet. The trial is looking at how this way of giving whole brain radiation affects thinking and memory. The source does not report any findings. Until the trial is done and reported, we will not know if this approach helps.
What this means, and what it doesn't
What it could mean: For now, this is a study, not care your own doctor can offer. If you are facing whole brain radiation, you could ask your care team whether a trial like this is worth looking into for you. They know your situation and can tell you if it makes sense to ask about.
What it doesn't mean: This does not mean the pulsed approach works better. A trial is a test, and the answer is not known yet. Joining a trial is not a guarantee that you will be helped. It is not a promise of a cure. Nobody can promise you a spot either. The trial team decides who can take part.
Source: ClinicalTrials.gov, July 29, 2026 · Read the original
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