Testing a radiation drug placed into the brain for glioma that has come back
Original title: Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people to find a safe dose.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests a radiation drug delivered straight into the brain in people whose glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary has returned or is growing.
Who this trial is for. This trial is for people with a malignant glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary that has come back or is getting worse after standard surgery, radiation, or chemotherapy. It tests a drug called rhenium nanoliposomes, fed slowly through a thin tube into the brain, at rising doses and volumes.
Where it stands. The trial has not reported results. Right now it is checking how safe the drug is, how well people handle it, and how it spreads in the brain. The team raises the dose step by step to find the highest dose people can take. After that, a larger group gets that dose to see if it helps. The answers are not in yet.
What this means, and what it doesn't
What it could mean: For some people whose glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary has returned, this is one study they may want to know about. If it sounds like a fit, you can ask your care team about it. They can look at your case and tell you what makes sense.
What it doesn't mean: This does not mean the drug works. A trial is a test, not a proven treatment. Being in one is not a promise that it will help you. It is not a cure.
Source: ClinicalTrials.gov, October 15, 2026 · Read the original
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