Testing a pill called JBI-778 for brain metastases, leptomeningeal disease, or high grade glioma that has come back
Original title: Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people to find a safe dose and see what the drug does.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing a drug taken by mouth in people whose cancer is in or around the brain.
Who this trial is for. This trial is for people with cancer that has spread to the brain, people with leptomeningeal disease, which is cancer in the lining and fluid around the brain and spinal cord, and people whose high grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary has come back. It is testing a drug called JBI-778 that is taken by mouth. The trial runs at more than one center. Doctors and patients both know which drug is being given.
Where it stands. This trial has not reported results. It is set up in two parts. The first part slowly raises the dose to find the highest dose people can take and the dose to carry into Phase 2. The second part gives that dose to more people to look for early signs of an effect on tumors. Along the way the team is measuring safety, how the body handles the drug, what the drug does in the body, and whether the drug reaches the fluid around the brain and spinal cord. The answers are not in yet.
What this means, and what it doesn't
What it could mean: There may be a new option being studied for cancer in and around the brain, which is hard to treat. Nothing is known yet about whether it helps. If this sounds like your situation, you could ask your care team about it and whether a trial like this makes sense for you.
What it doesn't mean: This does not mean JBI-778 works. A trial is a test, not a proven treatment. Joining a trial is not a guarantee that you will be helped, and the drug may cause side effects. This is not a promise of a cure. It also does not mean anyone can join. The trial team decides who is a fit.
Source: ClinicalTrials.gov, August 7, 2026 · Read the original
This plain-language summary was written by AI and published automatically after passing our automatic safety checks. How we write.