Testing a new drug with temozolomide and radiation for young people with high grade glioma
Original title: Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people, so the drug is still being studied.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests adding a drug called ADI-PEG 20 to temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary and radiation for young people with a newly found brain tumor.
Who this trial is for. This trial is for children, teens, and young adults who were just diagnosed with high grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary. It tests a drug called ADI-PEG 20 given together with temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary, also called TMZ, and radiation.
Where it stands. There are no results yet. Each person will start on a dose of ADI-PEG 20, and the dose will go up step by step. The team wants to see how this drug works with temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary and radiation.
What this means, and what it doesn't
What it could mean: Doctors are looking for new ways to treat this tumor in young people. If your child or a young adult you care for fits, you could ask the care team about this trial.
What it doesn't mean: A trial is a test. It is not a proven treatment. Being in it does not mean a person will be helped. This is not a promise of a cure.
Source: ClinicalTrials.gov, September 15, 2026 · Read the original
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