Testing a new drug called SRN-101 before surgery for adults with high-grade glioma that has come back
Original title: A Phase 1 Study of SRN-101 Administered Prior to Surgical Resection in Adults With Recurrent High-Grade Glioma.
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a first safety test of a new drug in a small group of people.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing a new drug, SRN-101, in adults whose high-grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary has come back and who can have surgery.
Who this trial is for. This trial is for adults whose high-grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary has come back and who can have surgery to remove it. They get SRN-101 before surgery. The drug is meant to kill tumor cells and help the body's immune system fight the cancer.
Where it stands. This is the first time SRN-101 is being tested in people. The trial has not reported any results yet. We do not know yet if the drug is safe or if it helps.
What this means, and what it doesn't
What it could mean: Researchers are trying a new way to treat high-grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary that has come back. If this sounds like your situation, you could ask your care team about it. The trial team decides who can join.
What it doesn't mean: This does not mean SRN-101 works. A trial is a test, not a proven treatment. Being in a trial does not mean you will get better. This is not a cure.
Source: ClinicalTrials.gov, September 18, 2026 · Read the original
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