Testing a leukemia drug, with or without sildenafil, in brain tumors
Original title: Asciminib With or Without Sildenafil for Brain Tumors
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a first test in people, at the earliest stage.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests whether a drug used for leukemia can reach brain tumors.
Who this trial is for. This trial is for people with brain tumors. It tests a drug called asciminib, given alone or with sildenafil. Asciminib is already approved for a blood cancer called chronic myeloid leukemia.
Where it stands. The trial has not reported results. Doctors do not yet know if asciminib can get into the brain and into brain tumors in high enough amounts. The body may pump the drug back out. This trial is set up to look at that question. The answer is not in yet.
What this means, and what it doesn't
What it could mean: Right now this is a question, not an answer. Asciminib is used for a blood cancer, and it is generally well tolerated there. Researchers want to know if it can help with brain tumors. Someone who thinks they might fit can ask their care team about it.
What it doesn't mean: This does not mean asciminib treats brain tumors. A trial is a test, not a proven treatment. Joining a trial is not a promise that it will help you. It is not a cure, and it is not a promise of one.
Source: ClinicalTrials.gov, September 11, 2026 · Read the original
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