Testing a daily pill to keep CNS lymphoma from coming back
Original title: Tirabrutinib Maintenance Versus Placebo in Patients With Primary CNS Lymphoma in Complete Remission (JCOG2104)
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage test in people, so we do not know yet if it works.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial is testing whether a daily pill can help keep primary CNS lymphoma from returning after treatment clears it.
Who this trial is for. This trial is for people newly diagnosed with primary central nervous system lymphoma, a lymphoma that starts in the brain or spinal cord. It is for those whose cancer went away completely after chemotherapy based on high-dose methotrexate, and who did not have whole-brain radiation after that. Some take a drug called tirabrutinib every day. Others take a placebo, which is a pill with no medicine in it. Which one a person gets is decided at random, and neither the person nor their doctor knows which it is.
Where it stands. This trial has not reported results. It is measuring how long people go before the lymphoma grows or comes back. It is comparing the daily drug to the placebo on that. People stay on their pill until the cancer grows or the side effects are too hard to handle. They visit the clinic once every 4 weeks for checkups and tests. The answer is not in yet.
What this means, and what it doesn't
What it could mean: For people whose CNS lymphoma has gone away after chemotherapy, the usual next step can be watching and waiting. This trial is asking if a daily pill during that time works better than watching and waiting. If your situation sounds like this, you could ask your care team whether a trial like this is worth looking into.
What it doesn't mean: This does not mean the drug works. A trial is a test, not a proven treatment. Joining one is not a guarantee that you will be helped, and it is not a promise of a cure. Some people in this trial get a placebo instead of the drug. Whether anyone can join is decided by the trial team, not by us.
Source: ClinicalTrials.gov, August 5, 2026 · Read the original
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