Testing a cannabis mouth spray and a drug sent into the tumor in new glioblastoma
Original title: Novel endOvascular Therapy With beVAcizumab and Cannabinoids for Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early safety test in people.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests whether two added treatments can be given safely with standard care.
Who this trial is for. This trial is for adults with newly diagnosed glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary. Everyone gets standard care, which is radiation with the chemotherapy drug temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary. The trial adds a daily cannabis-based mouth spray called nabiximols. It also sends the drug bevacizumab: A drug that acts on the blood vessels a tumor builds. In brain tumors it is used mainly for two things. One is to control symptoms from swelling. The other is to cut down how much steroid someone needs. See the glossary straight to the tumor through a thin tube.
Where it stands. The trial has not reported results. It is measuring how many people have serious side effects from the combined treatment. It is also measuring whether people can get and finish the planned treatment. And it is measuring how often the tube procedure works. The answers are not in yet.
What this means, and what it doesn't
What it could mean: This is an early safety test. It asks whether these treatments can be given safely and practically. Someone with newly diagnosed glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary who thinks they might fit could ask their care team about it.
What it doesn't mean: This does not mean the treatment works. A trial is a test, not a proven treatment. Being in a trial is not a guarantee that you will be helped. It is not a promise of a cure. We also cannot say who will be able to join.
Source: ClinicalTrials.gov, November 2, 2026 · Read the original
This plain-language summary was written by AI and published automatically after passing our automatic safety checks. How we write.