Studying gene changes in children treated for cancer, including brain tumors
Original title: Next Generation Sequencing of Normal Tissues Prospectively in Pediatric Oncology Patients
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
No phase is given, and this study collects information rather than testing a treatment.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study reads the genes of children with cancer to learn how inherited gene changes shape their illness.
Who this trial is for. This study is for children and young people treated for cancer at St. Jude Children's Research Hospital. That includes brain and other central nervous system tumors. The team collects and studies genes from the tumor and from the child's normal tissue, and looks at 150 genes that can raise cancer risk.
Where it stands. This study does not test a treatment. It gathers and studies gene information. The team wants to learn how inherited gene changes affect how a cancer shows up, how it responds to treatment, and how children do over the long term. Those answers are not in yet. The study has not reported results. The team expects about 2500 patients over the next 7 years.
What this means, and what it doesn't
What it could mean: Gene testing like this can help doctors understand a child's cancer better. It may also show whether a gene change runs in the family. That can help guide genetic counseling and follow-up care. A family who thinks this fits their situation could ask their care team about it.
What it doesn't mean: This does not mean a new treatment is coming out of this study. A trial is a test, not proven care. This study is not a treatment at all, and joining it is not a guarantee of any benefit. It is not a promise of a cure. Whether a family can take part is decided by the study team, not by us.
Source: ClinicalTrials.gov, July 22, 2026 · Read the original
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