Pulsed radiation compared with usual radiation for newly diagnosed glioblastoma
Original title: Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a large, late-stage test in people, but it is not approved care yet.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial compares radiation given in short bursts with breaks to the usual way of giving radiation.
Who this trial is for. This trial is for people newly diagnosed with a kind of glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary. Tests on the tumor show it is IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary wildtype and MGMT-unmethylated, a type less likely to respond to the chemo drug temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary. The trial compares usual radiation with pulsed radiation, which gives the same dose in short bursts with breaks in between.
Where it stands. The trial is checking if pulsed radiation helps people live longer. It is also checking if it helps protect memory and thinking. The answer is not in yet. The trial has not reported results.
What this means, and what it doesn't
What it could mean: The idea is that pulsed radiation may work better than usual radiation for this tumor type. If you or someone you care for has this kind of tumor, you could ask the care team about this trial. The trial team decides who can join.
What it doesn't mean: This is a test, not a proven treatment. No one knows yet if pulsed radiation works better than usual radiation. Being in a trial does not promise that you will benefit. It is not a cure.
Source: ClinicalTrials.gov, September 10, 2026 · Read the original
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