Proton radiation before surgery for high-grade brain gliomas
Original title: Preoperative Proton Irradiation for High-grade Brain Gliomas.
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early study to find out if the treatment is safe in people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing whether it is safe to give proton radiation to a brain tumor before surgery.
Who this trial is for. This trial is for people with a high-grade brain glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary who are going to have surgery. It tests giving proton radiation aimed at the tumor first, then doing the surgery. After surgery, people go on to the usual treatment of radiation with chemotherapy.
Where it stands. This trial has not reported results. It is looking at how well people handle the proton radiation given before surgery. It is also looking at the highest dose that is safe, and at how this affects the surgery itself. The answers are not in yet.
What this means, and what it doesn't
What it could mean: Giving radiation before brain tumor surgery is being tried out here. It is not part of normal care. If this sounds like your situation, you can ask your care team about it. They can tell you whether it makes sense for you and what the trial would involve.
What it doesn't mean: This does not mean the approach works. A trial is a test, not a proven treatment. Being in a trial is not a guarantee that you will be helped. It is not a promise of a cure. Whether anyone can join is decided by the trial team.
Source: ClinicalTrials.gov, July 17, 2026 · Read the original
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