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Proton radiation aimed away from the brain for cancer that has spread to the fluid around the brain and spine

Original title: BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor Malignancies

How far along is this research?

This is a trial that is enrolling or has been updated. It is not a finding yet.

This is a middle stage study, so the treatment is still being tested in people.

Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.

The trial team last updated this record on . Always check the trial page for the latest.

The short version

This study tests a form of proton radiation for adults whose solid tumor cancer has spread to the lining of the brain and spine.

Who this trial is for. This trial is for adults with leptomeningeal metastases from solid tumors. That means cancer has spread to the thin layers and fluid around the brain and spinal cord. It is testing a treatment called BRAVO proton craniospinal irradiation, which treats the brain and spine while trying to spare the brain itself.

Where it stands. The trial has not reported results. It is set up to measure how well this proton radiation works in these adults. That answer is not in yet.

What this means, and what it doesn't

What it could mean: For now, this only means the idea is being tested in people. Someone who fits this picture could ask their care team whether a trial like this makes sense for them. Your team knows your case and can explain the trade-offs.

What it doesn't mean: This does not mean the treatment is proven. A trial is a test, not care your own doctor can give you. Joining a trial is not a guarantee that you will be helped. It is not a promise of a cure.

Source: ClinicalTrials.gov, August 27, 2026 · Read the original

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