Protecting bone marrow to allow stronger chemotherapy for glioblastoma after surgery
Original title: hSTAR GBM (Hematopoetic Stem Cell (HPC) Rescue for GBM)
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a mid-stage test in people, not care your doctor can give yet.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests shielding bone marrow so glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary patients can get stronger chemo.
Who this trial is for. This is for people who recently had surgery to remove most or all of a glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary or gliosarcoma in the upper brain. It tests blood-forming stem cells given a lab-made gene, used with chemo drugs including temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary and carmustine.
Where it stands. This trial has not reported results. The idea is that the lab-made gene makes bone marrow harder for chemo to harm. That could let doctors raise the chemo dose to kill more tumor cells. Whether this works is not known yet.
What this means, and what it doesn't
What it could mean: If you recently had surgery for glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary or gliosarcoma, you could ask your care team about this trial. Only the trial team decides who can join.
What it doesn't mean: This trial is a test, not a proven treatment. Being in it does not promise that it will help you. It is not a cure. We do not know yet if this approach works.
Source: ClinicalTrials.gov, September 10, 2026 · Read the original
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