One man's treatment after urinary tract cancer spread to his brain
Original title: A Case Report of a 64-Year-Old Man With Urothelial Carcinoma With Brain and Leptomeningeal Metastases Treated With Intrathecal Methotrexate as Part of Multimodal Management.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was tested in people. That is the most reliable kind of research we share.
This is one patient's story, not a study that shows the treatment works.
The short version
Doctors describe how they treated one man whose urinary tract cancer spread to his brain.
What was studied. This is a report about one patient, a 64-year-old man. His upper urinary tract cancer spread to his brain and to the lining around his brain and spine.
What they found. He had surgery, chemotherapy, immunotherapy, and radiation over time. The cancer kept coming back and spread further. Doctors then put a chemotherapy drug, methotrexate, right into his spinal fluid. Cancer cells cleared from that fluid for a time, then the cancer grew again. He later died from his cancer.
What this means, and what it doesn't
What it could mean: For this rare kind of spread, doctors may give chemotherapy into the spinal fluid. It may hold the cancer back for a while. A team of different doctors plans this kind of care together.
What it doesn't mean: This is one person's story, not a study. It does not show the treatment helps other people. There was no cure here. The cancer came back, and he died from it. Ask your own care team what makes sense for you.
Source: PubMed, August 17, 2026 · Read the original
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