MRI scans may hint at a glioma's gene change before surgery
Original title: Multiparametric MRI radiomics model for preoperative prediction of IDH1 R132H immunopositivity status in adult diffuse Glioma.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was tested in people. That is the most reliable kind of research we share.
This was a look back at scans people already had, not a treatment you can get.
The short version
Doctors tested whether MRI pictures can point to a tumor's gene change before surgery.
What was studied. Researchers looked back at the records of 94 adults with glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary at one hospital. Each person had MRI scans before surgery. A computer model looked for patterns in the scans to guess the tumor's IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary gene status.
What they found. The model that used both scan types was right about 89.5% of the time. It spotted the gene change in 87.5% of the people who had it. It correctly ruled it out in 90.9% of the people who did not. The models did not clearly beat each other, so the small gaps could be chance.
What this means, and what it doesn't
What it could mean: The IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary gene status matters for how doctors plan care. If scans can hint at it before surgery, that could help with planning. For now this is only a test of the idea, not a tool a patient can ask for.
What it doesn't mean: This is not a new treatment, and it is not a cure. It does not change the care you get today. The study looked back at past records at a single hospital, and only a small group was held back for testing. The authors say it must be tested again in larger studies before anyone can trust it.
Source: PubMed, October 26, 2026 · Read the original
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