Grade 2 and grade 3 IDH-wildtype gliomas had very different outcomes
Original title: Long-term outcomes in IDH-wildtype (IDH-wt) gliomas with historical WHO grade 2 and 3 histology.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was tested in people. That is the most reliable kind of research we share.
This looked back at people who were already treated. It did not test anything new.
The short version
In a look back at 134 adults, people with grade 2 tumors lived much longer than people with grade 3 tumors.
What was studied. Doctors reviewed the records of 134 adults with IDH-wildtype gliomas that looked like grade 2 or grade 3 under the microscope. They were diagnosed between 1996 and 2019. The team looked at how long people lived and how long they went before the tumor grew.
What they found. For the whole group, the typical survival time was 35 months. The typical time before the tumor grew again was 20.9 months. People with grade 2 tumors did much better than people with grade 3 tumors. Typical survival was 94.5 months with grade 2 and 29.8 months with grade 3. In grade 3 tumors, giving radiation and chemotherapy one after the other worked about as well as giving them at the same time.
What this means, and what it doesn't
What it could mean: Tumor grade seems to matter a lot for what happens over time, even within this same tumor group. Your care team may use the grade when they talk with you about what to expect. For grade 3 tumors, the harder, all at once treatment did not do better here. That may be worth asking your doctor about.
What it doesn't mean: This does not mean grade 2 tumors are harmless, and it is not a cure. These numbers describe a group of people. They cannot tell you what will happen to you. This was a look back at old medical records, not a trial that tested treatments head to head. So it cannot prove one treatment plan is better than another. There is no new treatment here to ask for.
Source: PubMed, July 23, 2026 · Read the original
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