Focused sound waves plus T cell therapy for newly diagnosed diffuse midline glioma
Original title: Blood-Brain Barrier Disruption Using Exablate Magnetic Resonance-Guided Low Intensity Focused Ultrasound With Microbubbles in Combination With T-Cell Infusion in Patients With Newly Diagnosed Diffuse Midline Glioma (LIFT)
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early safety test in people.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests a new two part treatment for a hard to treat brain tumor.
Who this trial is for. This trial is for people newly diagnosed with diffuse midline glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary, an aggressive brain tumor. It tests low intensity focused ultrasound with tiny bubbles, then an infusion of the person's own T cells.
Where it stands. This is a phase 1 study. It looks at safety and at whether the treatment plan can be carried out. The trial has not reported results. The answer is not in yet.
What this means, and what it doesn't
What it could mean: The team wants to see if sound waves can help open the brain's natural shield. The idea is to let the T cells reach the tumor. Someone who fits this study could ask their care team about it.
What it doesn't mean: This does not mean the treatment works. A trial is a test, not a proven treatment. Being in a trial is not a guarantee that it will help you. It is not a promise of a cure.
Source: ClinicalTrials.gov, August 31, 2026 · Read the original
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