Dexbrompheniramine with daily temozolomide for high grade glioma that came back
Original title: Metronomic Temozolomide With Dexbrompheniramine for Recurrent High-Grade Glioma/Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people, looking at safety and the right dose.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests adding a drug called dexbrompheniramine to daily temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary.
Who this trial is for. This trial is for adults whose high grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary came back after standard chemo and radiation. It tests dexbrompheniramine taken with daily temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary, both taken at night.
Where it stands. The trial has not reported results. It is checking what medical problems people have on the two drugs together. It is also looking for the right dose of dexbrompheniramine. And it is asking whether the two drugs delay growth better than temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary alone. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: If your high grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary came back, this may be worth asking about. Your care team can tell you whether it fits your case.
What it doesn't mean: This does not mean the drug pair works. A trial is a test, not a proven treatment. Being in one is not a guarantee that it will help you. It is not a promise of a cure.
Source: ClinicalTrials.gov, October 5, 2026 · Read the original
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