Deferoxamine put into the spinal fluid for people whose cancer has spread to the lining around the brain and spinal cord
Original title: A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early safety test in people, and the team is still working out the right dose.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing whether a drug called deferoxamine is safe when it is put straight into the fluid around the brain and spinal cord.
Who this trial is for. This study is for people with leptomeningeal metastasis from a solid tumor cancer. That means the cancer has spread to the fluid and lining around the brain and spinal cord. The study is testing deferoxamine, also called DFO, given intrathecally. That means it goes right into the spinal fluid.
Where it stands. There are no results yet. The team is trying different doses to find the highest one that causes few or mild side effects. Once they find that dose, they plan to test it in more people to see if DFO is safe and works. They are also looking at how the body takes in, moves, and clears the drug, and how the body responds to it. The answers are not in yet.
What this means, and what it doesn't
What it could mean: This is one of the options a person with this kind of cancer spread might hear about. If this sounds like your situation, you can ask your care team about it. They can tell you if a study like this makes sense for you.
What it doesn't mean: This does not mean DFO is a treatment you can count on. A trial is a test. The point is to find out if the drug is safe, and nobody knows the answer yet. Joining a trial is not a guarantee that it will help you. It is not a promise of a cure.
Source: ClinicalTrials.gov, July 14, 2026 · Read the original
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