Comparing two radiation plans for large tumors that spread to the brain
Original title: Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a mid-stage test that compares two radiation plans already in use.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study compares two common ways to give focused radiation to large brain tumors that came from cancer elsewhere in the body.
Who this trial is for. This trial is for people with large brain metastases. These are tumors that started as cancer somewhere else and spread to the brain. It compares radiation given in a few separate stages with radiation split into several smaller doses.
Where it stands. The trial is looking at how well each plan works, how safe it is, and how the tumors respond. The answer is not in yet. The trial has not reported results.
What this means, and what it doesn't
What it could mean: Both radiation plans are already used in standard care. This study asks how they compare. If you have a large tumor that spread to the brain, you could ask your care team if this trial fits you.
What it doesn't mean: A trial is a test, not a proven answer. It does not yet show that one plan is better than the other. Being in a trial does not promise any benefit. This is not a cure.
Source: ClinicalTrials.gov, September 18, 2026 · Read the original
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