Comparing two kinds of radiation for cancer that spread to the fluid around the brain and spine
Original title: Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a large late stage study, but it is still a test.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
Doctors are comparing two types of radiation for cancer in the fluid around the brain.
Who this trial is for. This trial is for people with breast or non-small cell lung cancer. The cancer has spread to the fluid space around the brain and spinal cord. It compares proton radiation of the whole brain and spine with the usual x-ray radiation, which treats only certain areas.
Where it stands. This trial has not reported results. It is testing whether proton radiation of the brain and spine works better than the usual radiation. Researchers want to know if it can delay this cancer from getting worse. That answer is not in yet.
What this means, and what it doesn't
What it could mean: Radiation is already used to ease symptoms from this kind of spread. This trial asks if one way of giving it works better. Someone who fits could ask their care team about it. The care team can help weigh if it makes sense.
What it doesn't mean: This does not mean proton radiation is proven better here. A trial is a test, not care your own doctor can give you. Joining one is not a promise that it will help you. It is not a cure.
Source: ClinicalTrials.gov, August 17, 2026 · Read the original
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