Comparing Two Drugs for Glioblastoma That Has Come Back
Original title: Tamoxifen Versus Etoposide After First Recurrence in GBM Patients
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a phase 2 trial, so it is a mid stage test in people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests two drugs in people whose glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary has returned.
Who this trial is for. This trial is for people whose glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary has come back for the first time. It compares two drugs, tamoxifen and etoposide, to see which one helps more.
Where it stands. The trial is still going. It is comparing the two drugs in people with a first return of glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary. It has not reported results. No one knows yet which drug does better.
What this means, and what it doesn't
What it could mean: If your glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary has come back, you could ask your care team about this trial. They can tell you if it looks like a fit for your case.
What it doesn't mean: This does not mean either drug is proven to help. A trial is a test, not care that is known to work. Being in a trial is not a promise that it will help you. It is not a cure.
Source: ClinicalTrials.gov, November 4, 2026 · Read the original
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