Chemotherapy before radiation for newly diagnosed high-grade glioma
Original title: Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage test in people, and it is still being studied.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests giving chemotherapy before radiation in newly diagnosed high-grade glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary.
Who this trial is for. This trial is for people newly diagnosed with a high-grade glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary. It tests giving chemotherapy before radiation, starting with a drug called temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary.
Where it stands. This trial has not reported results. The team wants to learn if giving chemotherapy early works. They also note that brain scans are easier to read before radiation, since radiation changes how the brain looks. The answer is not in yet.
What this means, and what it doesn't
What it could mean: If this way of giving treatment works, the team could use it to test new drugs. Someone who fits might ask their care team about this trial.
What it doesn't mean: This does not mean this is proven care. A trial is a test, not a treatment your own doctor can give you. Being in a trial is not a promise that it will help you. It is not a cure.
Source: ClinicalTrials.gov, October 9, 2026 · Read the original
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