Bevacizumab did not help people live longer after glioblastoma came back
Original title: Post-Recurrence Outcomes Associated with a Bevacizumab-Containing First-Recurrence Strategy in Glioblastoma: A Propensity-Weighted Single-Center Cohort Study with Competing-Risk Analysis.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was tested in people. That is the most reliable kind of research we share.
This drug is already used today, but this study only looked back at past patient records.
The short version
A drug often used when glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary returns did not help people live longer in this study.
What was studied. Doctors looked back at the records of 166 people whose glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary had come back for the first time. 114 got a treatment plan that included bevacizumab. 52 got a plan without it.
What they found. 163 people had results the team could check. 136 of them died during the study. People given bevacizumab did not live longer. Their tumors also did not stay quiet for longer. Scans showed fewer cases of the tumor growing again, but more people died before any growth showed up on a scan. That last part was less certain.
What this means, and what it doesn't
What it could mean: Bevacizumab may not add extra time after glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary comes back. Scans can look better even when a person is not doing better. It can help to ask your doctor what the goal of a treatment is, and how you will know if it is working.
What it doesn't mean: This does not mean bevacizumab is the wrong choice for you. It is not a cure, and this study does not say it is one. The team looked back at old records from one hospital. Nobody was assigned to a group, so other differences between people may have changed the results. Some health details were missing. Talk with your own care team before changing anything.
Source: PubMed, August 18, 2026 · Read the original
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