Atovaquone Given With Radiation for Children With Cancerous Brain Tumors
Original title: Atovaquone Combined With Radiation in Children With Malignant Brain Tumors
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a first test in people, and it is checking safety.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing whether a drug called atovaquone can be given safely along with radiation in children with brain tumors.
Who this trial is for. This trial is for children with cancerous brain tumors, including newly diagnosed high-grade glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary, diffuse midline glioma, and DIPG. It tests giving atovaquone with standard radiation therapy, and it also tests taking atovaquone for a longer time in children whose high-grade glioma, diffuse midline glioma, DIPG, or medulloblastoma has come back or grown after radiation.
Where it stands. The trial has not reported results. It is measuring how safe atovaquone is with radiation, and how well children are able to handle it. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: This is an early look at whether atovaquone can be added to radiation safely. Families whose child seems to fit can ask their care team about it. The care team can explain what it would involve.
What it doesn't mean: This does not mean atovaquone is a proven treatment for these tumors. A trial is a test, not care that is known to work. Taking part is not a guarantee of any benefit. It is not a promise of a cure.
Source: ClinicalTrials.gov, August 3, 2026 · Read the original
This plain-language summary was written by AI and published automatically after passing our automatic safety checks. How we write.