An early drug slowed a rare infant brain tumor in mice
Original title: The CoREST complex inhibitor, corin, decreases tumor growth, increases cellular differentiation and extends lifespan in ATRT xenograft models.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was done in animals, not people. Most findings at this stage never become treatments.
This was only done in lab cells and in mice.
The short version
A drug called corin slowed a rare infant brain tumor in mice, but it has not been tested in people.
What was studied. Researchers tested a drug called corin on ATRT, a rare brain tumor that mostly shows up in babies. They tried it on tumor cells in the lab and on mice that had these tumors in their brains.
What they found. Corin slowed the growth of ATRT tumor cells in the lab. It made more of the tumor cells die, and it made them act more like normal nerve cells. In mice with these tumors, corin slowed tumor growth and the mice lived longer.
What this means, and what it doesn't
What it could mean: This points to a possible new way to attack ATRT. It gives researchers a reason to keep studying this drug. It does not change the treatment a doctor can offer today.
What it doesn't mean: This does not mean there is a new treatment for ATRT. The work was done in lab cells and in mice, not in children. That is very early stage research. Many drugs that help mice do not help people. This is not a promise of a cure, and years of testing in people would come first.
Source: PubMed, July 21, 2026 · Read the original
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