Adding Lenvatinib to Standard Stupp Treatment for Newly Diagnosed Glioblastoma With MGMT Methylation
Original title: STUPP Regimen With or Without Lenvatinib for Newly Diagnosed Glioblastoma With MGMT Promoter Methylation
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a Phase 2 trial, a middle stage test in people.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests whether adding a drug called lenvatinib to standard glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary treatment works better than standard treatment alone.
Who this trial is for. This trial is for people with newly diagnosed glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary whose tumor tests positive for MGMT promoter methylation. It compares the standard Stupp treatment plus lenvatinib against the standard Stupp treatment by itself.
Where it stands. There are no results yet. The trial is set up to look at how well each approach works and how safe it is. Those answers are not in yet. The trial has not reported results.
What this means, and what it doesn't
What it could mean: If this drug helps, it could become one more option added to standard care for this group of patients. Nobody knows that yet. Someone who was recently diagnosed and fits this picture could ask their care team whether a trial like this is worth looking into.
What it doesn't mean: This does not mean lenvatinib is a proven treatment for glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary. A trial is a test. It is run because the answer is unknown. Joining a trial is not a guarantee that you will be helped, and you could get the standard treatment alone. This is not a cure, and it is not a promise of one.
Source: ClinicalTrials.gov, August 10, 2026 · Read the original
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