A vaccine made from RNA, tested in adults and children with brain tumors
Original title: A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early safety test in a small number of people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial tests a new kind of vaccine in people with a fast growing brain tumor.
Who this trial is for. It is for adults with new glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary and children with new high grade glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary. The trial tests a vaccine made of RNA held in tiny fat particles.
Where it stands. The trial has not reported results. It is checking whether the vaccine can be made and given safely. It is also looking for the highest dose people can handle.
What this means, and what it doesn't
What it could mean: This vaccine is not care you can get from your own doctor today. Someone who fits this trial could ask their care team about it.
What it doesn't mean: This does not mean the vaccine works. A trial is a test, not a proven treatment. Being in one is not a promise that it will help. It is not a cure.
Source: ClinicalTrials.gov, October 30, 2026 · Read the original
This plain-language summary was written by AI and published automatically after passing our automatic safety checks. How we write.