A vaccine called IDH1-vac tested for newly diagnosed high-grade astrocytoma
Original title: IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade Astrocytomas
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a middle stage trial, so the vaccine is still being tested in people.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests a vaccine for a brain tumor with an IDH gene change: A small change in a tumor's IDH gene. It is the first thing your team looks at when naming an adult glioma, and it can affect which treatments are offered. Your pathology report says whether your tumor has it. See the glossary gene change.
Who this trial is for. It is for people just diagnosed with astrocytoma, CNS WHO grade: A number from 1 to 4 for how a tumor is likely to behave. Since 2021 it is written in plain numbers, not Roman ones. Gene results can set it too. See the glossary 3-4, that has the IDH1R132H change. People get up to 12 shots of either IDH1-vac or another vaccine called IS-vac, along with standard temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary.
Where it stands. The trial has not reported any results. It is set up to see how well IDH1-vac works over a period of three years. People are put into groups by chance. Neither they nor their doctors know which vaccine they get. Screening happens after radiation is finished, and shots start about 4 to 8 weeks later.
What this means, and what it doesn't
What it could mean: Right now this is a question being asked, not an answer. If this sounds like your situation, you can ask your care team about it. They can tell you if it fits your diagnosis and your plan.
What it doesn't mean: This does not mean the vaccine works. A trial is a test, not a proven treatment. Joining one is not a guarantee that you will feel better or live longer. It is not a promise of a cure, and it may not help at all.
Source: ClinicalTrials.gov, October 22, 2026 · Read the original
This plain-language summary was written by AI and published automatically after passing our automatic safety checks. How we write.