A study of gene changes in twins when one twin has a brain or spine tumor
Original title: Somatic Mosaicism in Twins Discordant for Childhood Cancer
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early study that gathers information from families, and no stage was listed.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study asks why one twin got a tumor and the other twin did not.
Who this trial is for. This small first study is for twin pairs where one twin has a brain or spine tumor. Families are found through a children's cancer registry called Project: EveryChild, or they can volunteer.
Where it stands. The study has not reported results. It is looking at changes in genes linked to cancer. These are changes that show up in only some cells. The answer is not in yet.
What this means, and what it doesn't
What it could mean: Right now this is a study, not care your doctor can give you. A family with twins in this situation might ask their care team about it. What it learns could help explain why one twin got a tumor.
What it doesn't mean: This does not mean there is a new treatment here. A trial is a test, not proven care. Joining one is never a promise that it will help. It is not a promise of a cure.
Source: ClinicalTrials.gov, October 1, 2026 · Read the original
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