A study drug called LMP744 for adults whose glioblastoma came back
Original title: Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people, and researchers are still learning if the drug is safe and if it helps.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is testing whether a drug called LMP744 can kill glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary tumor cells.
Who this trial is for. This trial is for people aged 18 years or older who have glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary that came back after treatment. It tests a study drug called LMP744, which is given through a tube placed in a vein in the chest.
Where it stands. Researchers want to see if LMP744 can kill glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary tumor cells. Participants have a biopsy first, then get the drug for 5 days in a row. They then have surgery to remove as much of the tumor as possible. Blood tests, heart tests, and imaging scans are done along the way. The trial has not reported results.
What this means, and what it doesn't
What it could mean: If your glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary came back, this is one study that is looking at a new drug. Someone who fits the description could ask their care team about it. The care team can explain what taking part would involve, including the surgeries and the monthly clinic visits.
What it doesn't mean: This does not mean LMP744 works. A trial is a test, not a proven treatment. Joining a study is not a guarantee that it will help you. It is not a promise of a cure. Whether someone can join is decided by the trial team.
Source: ClinicalTrials.gov, July 30, 2026 · Read the original
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