A rare brain lymphoma that first looked like sleepiness and fatigue
Original title: Case Report: Primary Central Nervous System Lymphoma With "Wine Glass" Sign Presenting as Somnolence and Fatigue.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was tested in people. That is the most reliable kind of research we share.
This is a report about one patient, not a test of a new treatment.
The short version
One man's brain lymphoma was easy to miss, because his first symptoms were sleepiness and feeling worn out.
What was studied. This is a report about one patient, a 55-year-old man who had carried the hepatitis B virus for a long time. His first symptoms were growing sleepiness and feeling tired all over, along with fever, confusion, and trouble thinking.
What they found. Brain scans showed unusual signals near the middle of his brain, in a rare pattern called the "wine glass" sign. Scans with dye did not show the pattern doctors usually expect, and tumor cells only turned up on the third test of the fluid around his brain and spine. A brain tissue sample confirmed the lymphoma, and his symptoms got better after a single dose of radiation.
What this means, and what it doesn't
What it could mean: This kind of brain lymphoma does not always look the way doctors expect. When someone gets very sleepy and tired with no clear cause, this cancer can be missed or found late. The report suggests that repeating the test on the fluid around the brain and spine, and doing a tissue sample early, can help find it sooner.
What it doesn't mean: This is one person's story, not a study. It does not test a new treatment, and it does not tell us how other patients will do. It is not proof of anything, and it is not a cure. It also does not mean that sleepiness or fatigue means someone has a brain tumor. Most people with those symptoms do not.
Source: PubMed, July 20, 2026 · Read the original
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