A protein helps brain tumor cells resist chemo, in lab and mouse tests
Original title: EAAT1 sustains redox homeostasis and temozolomide resistance through glutamate-dependent regulation of the Keap1/Nrf2 axis in glioblastoma.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was done on cells in a lab, not in people. It is a very early step.
This was only done in cells and in mice, not in people.
The short version
Removing a protein called EAAT1 made brain tumor cells easier to kill with a common chemo drug, in lab and mouse tests.
What was studied. Researchers looked at EAAT1, a protein that moves a body chemical called glutamate into glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary cells. They checked two large gene databases from patients, then used gene editing to remove EAAT1 from tumor cells and from tumors grown in mice.
What they found. In the databases, EAAT1 levels were high in glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary. Higher levels went along with poorer patient survival. Taking EAAT1 away weakened the cells' built in defenses and let damaging stress build up inside them. Those cells grew and moved less, and were more sensitive to the chemo drug temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary. Tumors in mice grew less too.
What this means, and what it doesn't
What it could mean: This points to a possible target for future drugs. If a drug could block EAAT1, it might help temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary work better. No such drug exists yet.
What it doesn't mean: This does not mean a new treatment is close. The work was done in cells and in mice, not in people. It is very early research, far from everyday care. There is nothing here you can ask your doctor for now, and it is not a cure.
Source: PubMed, August 29, 2026 · Read the original
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