A PET scan found measurable tumor in more people than MRI did
Original title: PET RANO 1.0 vs. RANO 2.0 criteria for trial eligibility in IDH-wildtype glioblastoma: a retrospective, comparative study.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was tested in people. That is the most reliable kind of research we share.
This was a look back at scans from people already treated, not a test of a new treatment.
The short version
A scan called PET spotted tumor that doctors could measure in far more people than MRI did.
What was studied. Doctors looked back at scans from 322 people with a brain tumor called IDH-wildtype glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary. Each person had both an MRI and a FET PET scan, either after first radiation or when the tumor first grew back.
What they found. After radiation, MRI showed measurable tumor in 57 of 112 people. PET showed it in 102 of 112. When the tumor first grew back, MRI showed measurable tumor in 137 of 210 people, and PET showed it in 201 of 210.
What this means, and what it doesn't
What it could mean: Trials often need a tumor that doctors can measure on a scan. Some people are turned away because MRI shows nothing to measure. PET scans might let more of those people join a trial.
What it doesn't mean: This is not a treatment, and it is not a cure. It does not mean PET helps anyone live longer or feel better. It was a look back at old scans at one hospital, not a planned study. The authors say it must be tested going forward before trials change who they let in.
Source: PubMed, August 14, 2026 · Read the original
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