A new pill tested alone or with other drugs for glioblastoma and some other cancers
Original title: A Study of Catequentinib Hydrochloride (AL3818) in Endometrial, LGSOC, STS or GBM Cancers
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test of a new drug in people.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests a new pill called catequentinib in adults with glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary and some other cancers.
Who this trial is for. This study is for adults whose cancer has grown or spread, including glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary. It tests a new pill called catequentinib, given alone or with other drugs, such as temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary or lomustine: A chemotherapy taken as a capsule, only occasionally rather than every day. It lowers blood counts weeks after a dose, which is why the doses are spaced out. See the glossary.
Where it stands. The trial has not reported any results. The first part looks for doses that are safe to give. The second part checks if the drugs keep glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary from getting worse for at least 6 months. For the other cancers, it checks if tumors shrink. Everyone in the study will know which drugs they get.
What this means, and what it doesn't
What it could mean: This is one more option being tested for glioblastoma: A glioma that is given grade 4, the highest grade. It grows fast. Treatment usually starts soon after it is found. It often means surgery, then radiation and chemotherapy. See the glossary. If you think you might fit, you could ask your care team about it. The trial team decides who can join.
What it doesn't mean: This is a test, not a proven treatment. Joining a trial does not mean the drug will help you. It is not a cure, and no one can promise that it will work.
Source: ClinicalTrials.gov, September 10, 2026 · Read the original
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