A new drug shrank brain tumors in mice
Original title: Discovery of LG-NE-29: An Orally Bioavailable GSPT1 Molecular Glue Degrader Effective in Glioblastoma Xenograft Models.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was done in animals, not people. Most findings at this stage never become treatments.
This was only done in cells and in mice.
The short version
Scientists built a new drug that made brain tumors smaller in mice.
What was studied. Researchers looked for proteins that glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary cells need to stay alive. They then built a new drug, called LG-NE-29, to destroy one of those proteins.
What they found. The drug made tumor cells break down a protein called GSPT1. Without that protein, the cells went under stress and died. In mice given the drug by mouth, the tumors got smaller.
What this means, and what it doesn't
What it could mean: This points to a new way to attack glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary cells. The protein GSPT1 may be a useful target for future drugs. Right now it is a research tool, not a medicine.
What it doesn't mean: This is not a treatment anyone can get today. The work was done in cells and in mice, not in people. No one knows yet if it is safe or helpful for humans. It is not a cure, and it is not close to one.
Source: PubMed, October 22, 2026 · Read the original
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