A new antibody slows brain tumor growth in lab and mouse tests
Original title: Activated ADAM10 targeting antibody 1H5 suppresses NOTCH-driven glioma progenitors
How far along is this research?
This is a preprint. Other scientists have not checked it yet, so treat it as an early signal rather than an answer.
This was only tested on cells in the lab and in mice.
The short version
Scientists tested a new antibody on brain tumor cells and in mice.
What was studied. Researchers looked at high-grade glioma: A tumor that starts in the glial cells. Those are the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4. The grade says how the tumor is expected to act. See the glossary, a fast-growing brain tumor. They tested an antibody called 1H5 on tumor cells from patients and in mice.
What they found. Tumor cells with more active ADAM10 were more easily killed by 1H5. The antibody turned down the NOTCH growth signal and made tumor cells die. In mice, it slowed tumor growth and helped them live longer.
What this means, and what it doesn't
What it could mean: An older way to block this same growth signal failed in people. It caused too much harm to the whole body. This antibody aims more closely at the tumor, so it may be worth testing in people later.
What it doesn't mean: This is early lab and animal work. No person was treated with 1H5 in this study. It is not something you can ask your doctor for, and it is not a cure. Many drugs that help mice do not end up helping people.
Source: bioRxiv (preprint), October 29, 2026 · Read the original
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