A molecule called DLK1-35 may help glioblastoma resist temozolomide
Original title: DLK1-35 Contributes to Temozolomide Resistance in Glioblastoma Through the miR-140-3p/NHE1/ERK-MGMT Axis.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was done on cells in a lab, not in people. It is a very early step.
This looks like early lab work on tumor cells, and the study details have not even been posted yet.
The short version
This is early lab research into why the chemo drug temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary stops working for some people with glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary.
What was studied. The full study is not available. Only the title was posted, with no abstract. The title says the team looked at a molecule called DLK1-35 and how it connects to glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary resisting temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary.
What they found. No abstract was posted, so the actual results are not available here. The title states that DLK1-35 helps glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary resist temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary. It also points to a chain of other molecules that may carry that effect. No numbers or details can be reported.
What this means, and what it doesn't
What it could mean: temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary is a chemo drug used for glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary. Over time it stops working for many people. Research like this tries to explain why that happens. It does not change any treatment available today.
What it doesn't mean: This is not a new treatment. It is early laboratory science about how tumor cells behave, and it is a long way from everyday care. There is no evidence here that anyone lived longer or felt better. It is not a promise of a cure. Because the abstract is missing, no one can judge how strong or reliable this work is.
Source: PubMed, July 23, 2026 · Read the original
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