A lab study finds a new target for slowing glioma growth
Original title: Pharmacological Blockade of NMUR2 Suppresses Glioma Growth by Inhibiting STAT5-Mediated Transcription of Cell Cycle-associated Genes.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was done on cells in a lab, not in people. It is a very early step.
This was only done in lab cells and animals, not in people.
The short version
Scientists found a protein on glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary cells that helps the tumor grow, and a drug that blocks it.
What was studied. Researchers studied glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary tumor tissue and glioma cells in the lab, plus animal models. They tested what happens when a receptor called NMUR2 is blocked or switched off.
What they found. NMUR2 levels were high in glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary tissue, and higher in higher grade tumors. When NMUR2 was silenced, the cells grew and moved less. The team screened 6,331 compounds and found one, called NNC 05-2090, that blocks NMUR2. It slowed glioma growth in cells and in animals, and it worked together with the chemo drug temozolomide: A chemotherapy taken as a capsule, used for some brain tumors. Your team checks your blood counts while you are on it. See the glossary.
What this means, and what it doesn't
What it could mean: This points to a new target that drug makers can now study. It may help explain part of why glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary grows.
What it doesn't mean: This is early lab and animal work. NNC 05-2090 has not been tested in people with glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary. There is no way to get this as a treatment today, and it is not a cure. Many drugs that work in cells and animals do not work in people.
Source: PubMed, July 30, 2026 · Read the original
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