A Higher Dose of Proton Radiation for Pituitary Tumors That Make Hormones
Original title: PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is a large late-stage trial, but it is still a test.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study asks if a stronger dose of radiation can help bring hormone levels back to normal.
Who this trial is for. This trial is for people with a pituitary tumor that makes hormones. It compares a higher dose of proton radiation with the usual dose of radiation, given for about 6 weeks.
Where it stands. The trial has not reported results. It will check how many people reach normal hormone levels in each group. People will be followed for at least 2 years. The team will also check the tumor, eyesight, thinking and memory, and quality of life.
What this means, and what it doesn't
What it could mean: If you have a pituitary tumor that makes hormones, you could ask your care team about this trial. Only the trial team can say who is able to join.
What it doesn't mean: This is a test, not a proven treatment. No one knows yet if the higher dose works better. Being in a trial does not promise that you will be helped. It is not a cure.
Source: ClinicalTrials.gov, September 10, 2026 · Read the original
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