A gene that may help glioblastoma grow faster
Original title: NUP35 drives the Warburg effect and malignant progression in glioblastoma by regulating GCKR stability and HK2 activation.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was done in animals, not people. Most findings at this stage never become treatments.
This was done in lab cells and animals, not in people.
The short version
Lab tests found a gene that seems to help brain tumor cells make quick energy.
What was studied. Researchers searched large public gene databases for genes tied to how glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary makes energy. They then tested one gene, called NUP35, in tumor cells and in animal tests.
What they found. NUP35 was high in glioblastoma: A glioma that is given grade 4. Grade 4 is the highest grade there is. The tumor grows fast. Treatment usually starts soon after it is found. It often means surgery, and then radiation and chemotherapy. See the glossary tissue. Higher levels went along with worse outcomes for patients. When the team raised NUP35, the cells made more of a waste product called lactate, spread more, died less, and tumors grew faster. The team also traced how NUP35 breaks down another protein, called GCKR.
What this means, and what it doesn't
What it could mean: This gives scientists a new target to study. It may help explain why these tumors grow so fast. Work like this can guide the search for future drugs.
What it doesn't mean: This is early lab work on cells and animals. There is no drug for it, and it has not been tested in people. It does not mean a cure, and it does not change the care you get today.
Source: PubMed, October 11, 2026 · Read the original
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