A gene signal tied to faster growing glioma
Original title: LAMTOR5-AS1 predicts poor prognosis and regulates glioma progression via miR-4653-5p/TCF7 axis.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was done on cells in a lab, not in people. It is a very early step.
This was lab work in cells and animals, not a treatment given to people.
The short version
Scientists found a gene signal that is higher in glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary and linked to worse outcomes.
What was studied. Researchers compared normal brain tissue with glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary tissue to measure a gene signal called LAMTOR5-AS1. They also looked at a large public cancer database and ran tests in lab cells and in animals.
What they found. glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary tissue had more of this gene signal than normal brain tissue. Higher levels went along with a higher tumor grade and a worse outcome. When the team lowered the signal in glioma cells, the cells grew and spread less.
What this means, and what it doesn't
What it could mean: Someday this signal might help doctors tell how a glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are given a grade from 1 to 4 describing how the tumor is expected to behave. See the glossary is likely to behave. It also gives researchers a new target to study for future drugs.
What it doesn't mean: This is early lab work. It is not a treatment, and it is not a cure. No patient was given a new drug in this study. There is no test like this in everyday care today. Work like this takes many years, and most of it never becomes a treatment.
Source: PubMed, October 6, 2026 · Read the original
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