A first test in people of the drug CT-179 for glioblastoma
Original title: OLIG2 Inhibitor CT-179 for Recurrent and Newly-diagnosed Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early safety test, and the first time this drug is given to people.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
Doctors are testing a new drug called CT-179 in people with glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary.
Who this trial is for. This trial is for people whose glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary has come back, and for people newly diagnosed with a type called MGMT unmethylated glioblastoma who can have radiation after surgery. It is testing a drug called CT-179 to see how safe it is, how well people handle it, what the body does with it, what it does in the body, and the highest dose people can take.
Where it stands. There are no results yet. This is the first time CT-179 is being given to people. The team is watching safety and side effects, and slowly raising the dose to find the highest dose people can handle. They also want to pick the dose to use in a Phase 2 study. Those answers are not in yet, and the trial has not reported results.
What this means, and what it doesn't
What it could mean: For now this only means researchers are starting to test CT-179 in people. It does not change treatment today. If your tumor sounds like the kind described here, you could ask your care team whether a trial like this is worth looking into for you.
What it doesn't mean: This does not mean CT-179 works. A trial is a test, not a proven treatment. Joining a trial is not a guarantee that you will be helped, and side effects are possible. This is not a promise of a cure. Whether anyone can join is decided by the trial team, not by us.
Source: ClinicalTrials.gov, July 31, 2026 · Read the original
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