A first test in people of a pill called JBI-778 for glioma that has come back, and for some other cancers
Original title: First in Human Multicenter Open Name Dose-increase, Consolidation Method to Study Safety Drug-level in Blood & Drug Metabolism Clinical Activity of Oral JBI-778 in Lung Cancer Patients With, Without Brain Metastasis IDH Mutated WHO Grade 3,4 Recurrent Glioma, Salivary Glands Tumor
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is the first safety test of a new pill in a small number of people.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study is trying to find a dose of a new pill, JBI-778, that people can take safely.
Who this trial is for. One group in this trial is people with WHO grade 3 or grade 4 glioma: A tumor that starts in the glial cells, the support cells of the brain and spinal cord. Gliomas are graded 1 to 4 by how fast they tend to grow. See the glossary with an IDH gene change: A small change in a tumor's IDH gene. Tumors with this change often grow more slowly and may respond to different treatments. Your pathology report says whether your tumor has it. See the glossary, where the tumor has come back. The trial also includes people with EGFR mutated lung cancer, with or without cancer that has spread to the brain, and people with a salivary gland cancer called ACC that is advanced or has spread. The plan is for 42 people to take JBI-778 by mouth, and people with glioma are added after the first dose steps are done in the other groups.
Where it stands. The trial has not reported results. It is measuring side effects, how much drug gets into the blood, what the drug does in the body, and whether the drug reaches the fluid around the brain and spine. It is also taking an early look at whether tumors respond. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: Someone who fits this picture could ask their care team whether this trial is worth looking into. The main goal right now is safety and finding the right dose, not proving the drug helps. Whether a person can join is decided by the trial team.
What it doesn't mean: This does not mean JBI-778 works. A trial is a test, not a proven treatment. Being in a trial is not a guarantee that you will do better. It is not a promise of a cure.
Source: ClinicalTrials.gov, August 10, 2026 · Read the original
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