A first safety test of selinexor added to standard glioblastoma treatment
Original title: Phase I dose escalation of the Exportin 1 inhibitor, Selinexor, in combination with chemoradiation in patients with newly diagnosed glioblastoma.
How far along is this research?
- Lab cells
- Animals
- Review
- Tested in people
This was tested in people. That is the most reliable kind of research we share.
This was a small, early trial in people to find a safe dose, not proof that it works.
The short version
A small first study found a dose of the drug selinexor that people with new glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary could handle alongside their usual treatment.
What was studied. Eleven adults with newly diagnosed glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary or gliosarcoma took part. Everyone got standard radiation and temozolomide chemotherapy. On top of that, they took a drug called selinexor. Doctors tried three different selinexor schedules to see how much people could take.
What they found. The dose people handled was 60 mg twice a week during weeks 1, 2, 4, and 5 of treatment. The highest schedule was too much for people. Two people on it had side effects that were too severe. Half the patients went at least 15.9 months before their tumor grew again. Half lived at least 17.4 months. Several people had changes on scans that looked like the tumor growing but were not, seen at 5, 9, 10, and 23 months after radiation. How people said they felt stayed steady over time.
What this means, and what it doesn't
What it could mean: Selinexor can be added to standard treatment at the right dose without causing side effects that are too severe. The scan changes hint that the drug may make radiation work better. That is only a hint so far. Doctors say larger studies are needed to find out.
What it doesn't mean: This does not mean selinexor is a treatment you can ask for today. This was a phase I trial. That is the earliest kind of test in people. Its main goal was to find a safe dose, not to prove the drug works. Only eleven people took part. That is far too few to know if it truly helps anyone live longer. It is not a cure, and it is not a promise of one.
Source: PubMed, July 7, 2026 · Read the original
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