A drug switched on by sound waves for glioblastoma that came back or is growing
Original title: Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early test in people, mostly checking safety and dose.
Status: Recruiting. It is looking for patients now. Talk to your care team about whether it fits you.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This study tests a drug that is turned on by focused sound waves aimed at the tumor.
Who this trial is for. This trial is for people with glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary that is growing or has come back after getting better. It tests a drug, SONALA-001 or 5-ALA HCL, given with focused ultrasound that is guided by MRI. The drug sticks to the tumor, and the sound waves are meant to turn it on there.
Where it stands. This trial has not reported results. The team is checking how safe the treatment is and how well people handle it. They are also looking for the best dose and whether it helps. Those answers are not in yet.
What this means, and what it doesn't
What it could mean: This is one more idea being tested for glioblastoma: The fastest-growing type of glioma (grade 4). Treatment usually starts soon after diagnosis: surgery first, then radiation and chemotherapy. See the glossary that keeps growing or comes back. If that sounds like your situation, you can ask your care team about it. They know your case and can tell you if it is worth looking into.
What it doesn't mean: This does not mean the treatment works. A trial is a test, not proven care. Joining a trial is not a promise that you will be helped. This is not a cure, and no one can say yet if it will help anyone.
Source: ClinicalTrials.gov, August 25, 2026 · Read the original
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