A drug given into the spinal fluid for lung cancer that has spread to the lining of the brain
Original title: Safety and Efficacy of Intrathecal Sacituzumab Tirumotecan for Leptomeningeal Metastasis in EGFR-TKI-Resistant Non-Small Cell Lung Cancer
How far along is this research?
This is a trial that is enrolling or has been updated. It is not a finding yet.
This is an early safety test in a small number of people.
Status: Not yet recruiting. It has not opened yet. Ask your care team to watch for it if it looks like a fit.
The trial team last updated this record on . Always check the trial page for the latest.
The short version
This trial is testing whether a drug called sacituzumab tirumotecan can be given safely into the spinal fluid when lung cancer has spread to the lining of the brain and spinal cord.
Who this trial is for. This trial is for people with non-small cell lung cancer that has an EGFR gene change and has spread to the lining of the brain and spinal cord, after EGFR-TKI treatment stopped working. It tests the drug sacituzumab tirumotecan given straight into the spinal fluid through a small port called an Ommaya reservoir, starting at a low dose and stepping up.
Where it stands. This trial has not reported results. It is watching for side effects and trying to find the right dose to carry forward. It also looks at nerve symptoms, tests of the spinal fluid, and brain scans. The drug is given every 14 days. The answers are not in yet.
What this means, and what it doesn't
What it could mean: If this describes your situation, it may be worth asking your care team whether a trial like this is something to look into. They can explain the risks and whether it fits your case.
What it doesn't mean: This does not mean there is a new treatment available. A trial is a test, not a proven treatment. Being in a trial is not a guarantee that it will help you. It is not a promise of a cure. The safest dose is still being worked out.
Source: ClinicalTrials.gov, July 14, 2026 · Read the original
This plain-language summary was written by AI and published automatically after passing our automatic safety checks. How we write.